Okay, so, the configuration system is extremely frustrating...
I changed to the 7502 BIOS to test it... I have to go game-by-game and change the BIOS to load. Aaarrrrggghhhh
Schtruck, a suggestion: Make System only accessible before you load an ISO, and have the settings global (no need to select save default config) and then make Audio/Video/Input dependant on the game, with it's config being saved and loaded only for that game (like it is currently).
It's just extremely confusing because I can't seem to find a rhyme or reason to which settings are global and what aren't...